CBD oil information.2018-10-31T12:33:14+00:00

CBD oil information.

CBD oil information.

CBD oil information.

Product information full spectrum CBD oil.

The raw paste that I use to prepare the oil comes from a supplier located in Eastern Europe.

They run a farm that specializes in producing Hemp for CBD oil/paste.

What they produce is some of the best and most potent CBD it is possible to make.

According to a new report the World Health Organization declares that the main ingredient in medical cannabis to be nonaddictive and nontoxic.

The World Health Organization, a U.N. agency that focuses on public health said that “In humans, CBD exhibits no effects indicative of any abuse or dependence potential,” Researchers with the WHO spent A significant period of time looking into CBD, which is the non-psychoactive ingredient in marijuana that’s often used for medical purposes.

 It often comes in several forms such as oils, drops and capsules.

The message that should be taken from all of this should be that CBD is widely regarded as a very safe and highly useful therapeutic medication.

There is virtually no side effects  or risk for addiction/withdrawal from taking CBD.

While a vast quantity of research is still needed to fully understand the interactions it may have with other medications.

However CBD has the potential to actually eliminate the need to take multiple medications due to its wide range of uses or at least reduce a persons current prescription drug use.

Summery

A 10 ml bottle contains 260 drops.

1 drops of 1000mg full spectrum CBD oil gives approximately 3.83 mg of CBD.

3 drops of 1500mg equals 17.3mg

3 drops of 3000mg gives 34.5mg CBD

At that dose it is advisebly to take: 1 drop every 2 hours to avoid any complications if you are on prescriptions drugs.

CBD-Drug Interactions: Role of Cytochrome P450

In sufficient quantities, CBD will temporarily deactivate cytochrome P450 enzymes, affecting how the body will metabolize a wide range of compounds.

Scientists are taking a closer look at the interactions between CBD and other drugs. Cannabidiol (CBD) is set to become widely available in pharmaceutical, nutraceutical, and herbal preparations so knowing its interactions is essential.

CBD is a cannabis compound  that has safe, non-intoxicating, and non-addictive significant therapeutic attributions but in some cases CBD-drug interactions may be  problematic .

Other plant cannabinoids as well as CBD can potentially interact with many pharmaceuticals compounds by inhibiting the activity of liver enzymes  cytochrome P450.

The function of this enzyme group is to metabolizes a significant amount of the drugs we consume, thats more than 60 percent of  medication on the market .

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IF tken in large enough dosages CBD will temporarily deactivate cytochrome P450 enzymes which will alter how we metabolize tetrahydrocannabinol (THC), which causes the high that cannabis is famous for.

Metabolizing CBD

The interaction between CBD and cytochrome P450 is pivotal;  they deactivate each other.

It was found in Preclinical research that while CBD is metabolized by cytochrome P450 enzymes it also functions as a “competitive inhibitor” of the same  enzymes.

This happens when CBD occupys the site of enzymatic activity, it displaces the chemical competitors and thus prevents cytochrome P450 from metabolizing other compounds.

The competitive inhibitor degree that cannabidiol will have on the liver enzymes depends on how tight the bond is between CBD and the active site  before and after oxidation.

The amount of CBD that is administered can greatly effect this.

As well as the amount of CBD the unique attributes of the person that is taking the medication and whether the CBD is an isolate or a whole plant remedy will also influence this .

It is important to note that if the dosage of cannabidiol is low enough, there will be no noticeable effect on CYP activity, but may still have other effects.

It has not as yet been clearly established just at what dose which CBD does not interact with other drugs.

In 2013 a report was released on a clinical trial that used GW Pharmaceutical’s Sativex. Sativex is a  CBD-rich sublingual spray that is whole plant based. The trial found that when approximately 40mg of CBD were administered no interactions with CYP enzymes occured.

However a later clinical trial found that when administered orally  25mg CBD was found to significantly block the metabolism of an anti-epileptic drug.

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So how is the metabolic breakdown of THC impacted by the CBD-generated changes in cytochrome P450 activity? Studies conducted on animals indicate that when pretreated with CBD  brain levels of THC increased.

This effect occurs because CBD when its functioning as a competitive inhibitor of cytochrome P450 it slows down the rate at which THC is converted into its more potent metabolite, 11-OH-THC.

Thus this effect means THC will  remain active for a longer period of time, however the extended buzz is  somewhat blunted under the influence of cannabidiol.

There are other factors that figure prominently in whether CBD’s will  lessen or neutralize the THC high.

Grapefruit and Ganja

A research pharmacologist named Lester Bornheim from the University of California in San Francisco was one the first scientists that studied the metabolism of CBD.

 He received a NIDA grant in 1987 so that he could investigate the effects of phytocannabinoids on cytochrome P450 (CYP) liver enzymes.

He found THC and cannabinol (CBN) also inhibit CYP activity but of all the plant cannabinoids studied CBD was the strongest at deactivating cytochrome P450.

“ Cytochrome P450 is a very unusual enzyme. Most of the other enzymes are designed to fit one particular substrate and carry out a single chemical process resulting in a single product,” Bornheim noted.

He also noted Numerous drugs are substrates for cytochrome P450 and seems to function generically like a breakdown mechanism for a wide range of exogenous and endogenous substances.

In 1999, Bornheim drew attention to the idea that CBD could possibly interfere with the metabolism of many medications when he addressed the annual gathering of the International Cannabinoid Research Society (ICRS) .

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However a year before Bornheim proposed this idea, a team of  scientists from Canada identified particular compounds in grapefruit that  could inhibit the expression of some cytochrome P450 enzymes.

Hense this is why doctors will very often warn patients not to eat grapefruit before taking their meds.

  Bergapten which is the strongest of grapefruit components that can inhibit CYPs turns out to be less potent as an  inhibitor of cytochrome P450 enzymes than CBD.

 So in practical terms what does this mean for patients using medical marijuana that are also on a CBD-rich treatment regimen  but who also take a medication such warfarin , which is a prescription blood-thinner like , for example?

By inhibiting the enzymes the CBD will increasing the duration of action and effect because it reduces the degradation rate of the warfarin.

It is therefore essential that a person that is on a CBD-rich product should pay close attention to changes in blood levels of warfarin, and if necessary adjust dosage accordingly  as instructed by their doctor.

Cancer and Epilepsy

In terms of cancer treatment, doctors often struggle to find the maximum dose of chemotherapy that will not be catastrophically toxic so it is extremely important that the precise dosing is used.

The CYP enzymes are oxidized several chemotherapy agents either before their inactivation or excretion.

This means that  the same dose of chemotherapy may produce a higher blood concentration in patients using CBD.

If the metabolism of the chemotherapy is inhibited by CBD and the dosage adjustments aren’t made, the agent of chemotherapy being used  could accumulate  to highly toxic levels within the body.

However, the many cancer patients who use cannabis to cope with the terrible side effects that come with  chemotherapy there have been very few  adverse cannabinoid-drug interactions reported.

 There is the possibility that whole plant cannabis would have different interactions than the isolated CBD that is used in most research settings.

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It is thought that the cytoprotective effect cannabinoids possess may mitigate some of the toxicity that occurs with chemotherapy.

Some patients with epilepsy have had a few issues with regard to the interaction that CBD has with their anti-seizure medication.

Massachusetts General Hospital conducted a small clinical study.

The study involved children that had refractory epilepsy.

The results found an elevation in plasma levels and an increas in the long-term blood concentrations of clobazam and norclobazam (which are an anticonvulsant medication) occurred when they were given CBD, which is an active metabolite of this medication.

A reduction in the dose of clobazam was needed to reduced the side effects in the majority of the  childrenin the study.

The result is not surprising given the drug interaction caused by the fact that both clobazam and CBD are metabolized by cytochrome P450 enzymes.

Published in May 2015, the study concluded that “CBD is a safe and effective treatment of refractory epilepsy in patients receiving [clobazam].”

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But the report also emphasized the importance of monitoring blood levels for clobazam and norclobazam in patients using both CBD and clobazam.

Dr. Bonni Goldstein has observed cases in which small doses of high-CBD/low-THC cannabis oil concentrate seemed to aggravate seizure disorders rather than quell them.

How could this happen, given CBD’s renown anti-epileptic properties?

A 1992 review by Lester Bornheim and his colleagues indicated that CBD inhibits some cytochrome P450 enzymes at smaller doses than what is required for CBD to exert an anti-epileptic effect.

This means that a certain dose of CBD could alter the processing of an anti-epileptic drug taken by the patient, but this amount of CBD might not be enough to provide any anti-epileptic relief itself.

The advice some physicians offer in this situation may seem counterintuitive: Increase the dose of CBD—perhaps even add a little more THC (or THCA, the raw, unheated, non-psychoactive version of THC)—and this may be more effective for seizure control.

Enigmatic Enzymes

But why would preventing the breakdown of an anti-epileptic drug reduce its effect? There are a number of possible answers, depending on the drug in question.

The active component of the drug (the chemical that exerts an anti-epileptic effect) may be a breakdown product of the actual drug taken. So, by slowing the metabolism of the original drug, CBD would make that drug less active.

Other explanations are conceivable.

For example, if the activity of certain CYPs is slowed, the drug may be broken down by another metabolic pathway, the products of which could then interfere with the drug’s activity.

Or perhaps the inhibition of CYPs is not the predominant way that CBD interacts with certain anti-epileptic medications.

To complicate matters even further, a presentation by Dr. Kazuhito Watanabe at the 2015 International Cannabinoid Research Society meeting in Nova Scotia disclosed preliminary evidence that cannabidiol may “induce”—meaning amplify the activity of—some cytochrome P450 enzymes.

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(Induction of a protein involves increasing the transcription of its corresponding mRNA, which leads to the greater synthesis of the protein.)

This suggests that CBD can either increase or decrease the breakdown of other drugs. Again, it depends on the drug in question and the dosages used.

Any pharmaceutical, nutraceutical or green rush scheme to exploit the therapeutic potential of CBD must reckon with the fact that cannabidiol can both inactivate and enhance various cytochrome P450 enzymes in the liver—and this can potentially impact a wide range of medications.

Drug interactions are especially important to consider when using life-saving or sense-saving drugs, drugs with narrow therapeutic windows, or medications with major adverse side effects.

In particular, those who utilize high doses of CBD concentrates and isolates should keep this in mind when mixing remedies.

CBD oil information

One of the most frequent questions I get asked about our CBD oil is why it is so expensive, and this question usually comes from people who see hemp seed oil in supermarkets at very low prices and do not understand the difference.

The short answer is because CBD oil is not exactly the same as hemp-seed oil, and also because the extraction techniques used for producing the cannabinoid-rich products are VERY different from those used for obtaining oil from hemp seeds.

Super Critical CO2 extraction

The much more expensive but non-toxic and extremely efficient method to obtain CBD oil is CO2 extraction. This requires complex equipment and expertise, but uses safe solvents and ensures a highly potent and pure extract.

The CBD oil obtained through supercritical extraction is a full spectrum cannabinoid-rich product, with numerous health benefits.

CBD  short for cannabidiol the list of medical benefits of this cannabinoid just keeps getting longer.

Unlike THC, CBD is non-psychoactive.

It’s also legal in the EU.

Time will come when mainstream media has learned that CBD had medical value.

To give you a quick summary, here are a just a handful of conditions full spectrum CBD oil can treat:

Epilepsy

Cancer

Depression

Anxiety

Psychotic Disorders

Chronic Pain

Diabetes

The lesser known cannabinoids

Full spectrum CBD oil information

2. CBC

Also known as Cannabichromene, CBC is the third most common cannabinoid in the marijuana
plant overall.

In some strains, CBC may even take dominance over CBD.

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Like CBD, cannabichromene is non-psychoactive.

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Here’s what you can  expect from CBC:

Anti-Inflammatory

CBC is effective at fighting inflammation on its own but 2010 research has found that it’s even more effective when combined with THC.

These findings help support the idea that cannabinoids work synergistically with each other.

Scientists have been successful in finding and isolating over 113 different compounds in the marijuana plant.

The strongest medicine is created when different components work in harmony with one another.

Anti-Tumor

When coupled with THC and other cannabinoids, CBC has also shown  promise in fighting breast cancer.

The anti-tumor effects of CBC alone are not quite as exciting as the potential of CBD, THC, and CBG but together they make for one powerful tumor-fighting combination.

Anti-Depressant

In the science world, there’s a sure-fire way to test if a rodent is depressed. You suspend it by its tail and watch to see how much it struggles to get away.

The more it struggles, the more elevated the mood of the mouse.

The test is known as the Tail Suspension Test (TST). Researchers from the University of Mississippi found that mice treated with CBC struggled significantly more than mice treated with other cannabinoids.

The amount the mice struggled depended on how much CBC they were given.

Mice given 40mg of CBC struggled less than mice that were given 80mgs.

Anti-Fungal

In a review of cannabinoid literature, author Ethan Russo reported that CBC was mildly anti-fungal.

Encourages Brain Growth

2013 study found that CBC may actually help you grow new brain cells.

Regardless of your age, cells in certain portions of your brain continue to grow through a process known as neurogenesis.

The brain portions affected are responsible for memory and learning.

You run the risk of developing diseases like Alzheimers when your brain stops developing new cells in these areas.

4.CBG

CBG is short for cannabigerol.

This cannabinoid is found early on in the growth cycle, which makes it somewhat difficult to find in large quantities.

CBG, however, is non-psychoactive.

This means that it can be cultivated via hemp.

The medical potential of CBG makes it a prime target for research these days.

Antibiotic

Cannabigerol was another one of the cannabinoids tested on the MRSA virus in 2008.

As far as antibiotic properties go, CBG was stronger than CBN and comparable to CBD. CBG is also known to be mildly anti-fungal.

Research as early as 1982 found that isolated CBG is antimicrobial and kills various types of bacteria and fungi.

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Possible Treatment for Psoriasis

This cannabinoid is one that just so happens to be good for your skin.

Not only does it help prevent the reddening of the skin but it’s been shown to have therapeutic potential for skin conditions like Psoriasis.

 

Pain Reliever

CBG is reportedly a more potent pain reliever than THC.

Anti-Tumor

Back in 1998, Korean researchers found that CBG was effective at slowing the growth of cancerous cells in the mouth.

More recent research published in the British Journal of Pharmacology found that CBG also had mild anti-tumor effects in prostate cancer cells.

The study focused on non-THC cannabinoids.

It was CBD that really shined through as a potential treatment for prostate cancer, while CBG did have an effect on tumor growth.

Antidepressant & Mood-Stabilizer

researchers found As early as 1975,  that CBG prevented the uptake of amino acids that help regulate mood.

GABA The amino acid in question,  was better regulated by CBG than THC or CBD.

Studies have shown that CBG is a moderate anti-depressant, working to increase serotonin levels in your brain.

The antidepressant effects of CBG were first found in 2006 in by Richard Musty and Richard Dayo who tests conducted on lab rats.

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5.THCv

 

Short for tetrahydrocannabivarin, THCv is another cannabinoid that works in tandem with THC.

Studies cite that THCv has about 20% the psychoactive capacity as THC and recent research has shown
that THCv actually mitigates some of the negative psychoactive impacts of THC.

Anticonvulsant

Researchers out of Berkshire UK put the anti-epileptic properties of THCv to the test in rat brains.

First, they tested whether or not THCv stopped seizure-like activity in brain slices.

THCv reduced the amount of convulsive “bursts” observed when the brain segments were treated with the compound before seizures were induced.

It was then tested whether or not the cannabinoid stopped convulsions in adult rats.

They found that THCv significantly reduced seizure incidence.

 

Neuroprotective

You’re own experience with smoking weed shows you that you might be a little slowed down after smoking a high-THC strain.

This is where THCv comes in handy.

Smoking a strain high in THCv may help mitigate some of the short-term memory and speech impairment that goes hand-in-hand with being a little too high.

 

Promotes Weight Loss

There are several studies that highlight the appetite suppressant effects of CBD, more research is more conducted linking THCV and weight loss.

 Last year C4 Laboratories in Arizona published a paper citing evidence that THCV reduced the body fat and boosted energy metabolism in mice.

 

6.CBDv

CBDv is short for cannabidivarin.

Research has been carried out on CBDv with promising results.

There are similarities between CBDv and CBD, CBDv is a degraded version of the cannabinoid which changes  the
molecule in small but significant ways.

 

CBDv can provide several benefits:

 

Anti-Epileptic

It was announced in the UK that GW Pharmaceuticals have a patent for CBDv .

GW Pharma can now proceed with creating a CBDv-based anti-epileptic drug.

Phase 2 trials for the drug are currently underway.

A wave of research published back in 2012 and 2013 paved the way for the patent.

CBDv was identified as a strong anticonvulsant in two separate studies.

In 2012 the first study found that the cannabinoid stopped seizures in mice and rats.

second study was conducted, also using rats as subjects and confirmed the first study’s findings.

Subsequent Studies continue to corroborate these findings.

 

Anti-Nausea

When CBDv  was used in  patients with stomach or gastrointestinal issues it was shown to be very useful.

 In 2013  the University of Ontario found that CBDv has significant applications in fighting nausea.

It was proven that nausea in rats treated with both CBDv and THCv was significantly reduced .

 

7. Delta(8)-THC  

THC is know as Delta(9)-THC.

This version is slightly different.

Delta(8) has a reduced psychoactive effect than “regular” THC in adults.

Research has claimed that Delta(8) has neuroprotective and anti-anxiety properties. That makes it an interesting companion to the more regular psychoactive THC.

Further research needs to be carried out to confirm the effect this compound has ad how it acts inside the body.

 

Here are a couple of additional benefits you can expect from delta(8)-THC:

Appetite Stimulant

It is widely thought that the familiar or regular THC  is what gives you the munchies, however when experiments on mice were carried out it was found that delta(8) increased the rodents’ appetite significantly more than delta(9).

Anti-Nausea

Back in 1995, 8 children with cancer were treated with delta(8)-THC during the course of chemotherapy.

The results of the study were actually a little odd.

While nausea and vomiting were reduced in all cases, delta(8)-THC also did not produce any psychoactive response in the children.

They were between 2 and 13-years-old.